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AIM:To detect the effect and underlying mechanism of parthenolide ( PN) on neointimal hyperpla-sia.METHODS:After 1 week of high-fat feeding, 30 male New Zealand white rabbits (2.0~2.3 kg) were randomly di-vided into 6 groups: sham +NS, rabbits received 0.9% normal saline after sham operation; sham +DMSO, rabbits re-ceived DMSO after sham operation;balloon injury(BI)+NS, rabbits received NS after balloon injury;BI+DMSO, rabbits received DMSO after balloon injury;BI+PN low, rabbits received PN at 1 mg/kg after balloon injury;BI+PN high, rab-bits received PN at 2 mg/kg after balloon injury .The drugs were intraperitoneal injected once a day after the operation until sacrifice.After fed with high-fat diet for 4 weeks, the intima-media thickness, the expression of caspase-1, IL-1β, the lev-els of IL-8, TC, TG, LDL and HDL in the serum were measured .RESULTS:Compared with sham +DMSO group, the thickness of intima, the amount of caspase-1, IL-1βand IL-8 in BI +DMSO group were significantly increased ( P <0.05).The levels of caspase-1, IL-1βand IL-8 were significantly decreased in BI +PN high group compared with BI +DMSO group (P<0.05).CONCLUSION:Neointimal hyperplasia is suppressed by PN after balloon injury , the potential mechanism may be associated with its anti-inflammatory role .
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Based on a small-scale questionnaire survey, the study analyzed the dilemma of medical students in clinical training, discussing how young teachers should guide the students get out of the dilemma, including how to resolve the conflict between further study and career, acquire more practicing opportunity, improve their communication ability with patients, and value their lives finally.
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Objective:We study on the relationship among the concentration of serum uric acid,the concentration of serum C-reactive protein and the severity of coronary lesions.Methods:176 patients were divided into two groups(groupⅠ:coronary artery lesions group and groupⅡ:non-coronary artery lesions group) by coronary angiography,the concentration of serum uric acid and serum C-reactive protein were measured in each patients.the relationship among the severity of coronary lesions and the concetration of serum uric acid,the concetration of serum C-reactive protein were analysed by liner-correlated analysis.Results:the concentration of serum uric acid and serum C-reactive protein were increased in the groupⅠ,the concetration of serum uric acid and serum C-reactive protein correlated with Gensini scores.Conclusion:The results suggest that the increased serum uric acid and C-reactive protein play important role in the formation and development of coronary artery disease.
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180)were 0.74?0.13,0.88?0.12,0.94?0.12 and 0.97?0.15 mm,respectively.ASI was positively related with IMT(r=0.395,P
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Objective:To investigate heart rate variability(HRV)and its circadian rhythm of patients with isolated systolic hypertension.Methods:HRV was evaluated by using 24-hour Holter monitoring in 92 isolated systolic hypertensive patients, and compared with age-matched normal controls.Furthermore,HRV and its circadian rhythm were evaluated in two subgroups with and without left ventricular hypertrophy(LVH).Results:All HRV time domain index were lower among patients than normal controls.As compared with the patients with and without LVH,rMSSD and pNN50 were significantly decreased in patients with LVH.The circadian rhythm was blunted in patients without LVH,but it was absent in patients with LVH.Conclusion:Our results suggest that HRV is decreased in isolated systolic hypertensive patients.Parasympathetic tone is lower in patients with LVH than those without LVH,and the sympathetic/parasympathetic tone is altered.
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Objective To observe the effects of indole-3-carbinol on neointimal hyperplasia and restenosis of rat artery after balloon injury and the possible mechanisms.Methods Balloon dilation was used to establish the neointimal injury model of left carotid artery in rats.Twenty Sprague-Dawley rats were randomly divided into single balloon dilation group(control group)and balloon dilation followed by indole-3-carbinol therapy group(therapeutic group).After balloon dilation,indole-3-carbinol(12.5,25,50 mg/d)was applied to the rats for 7 days respectively.The rats were killed two weeks after balloon dilation and the injured vascular specimens were harvested for pathologic examination and immunohistochemical staining.Results ①The neointimal thickness,neointimal area in the therapeutic groups were significantly less than that of the control group(P
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0.05).The intimal thickness was decreased in high-dose DIM group compared with model group and low-dose DIM group(P
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Objective:To investigate the characteristics of brachial ankle pulse wave velocity(baPWV)in patients with essential hypertension,and that in patients with essential hypertension associated with coronary artery disease.Methods:The baPWV of 28 patients with essential hypertension was measured,the baPWV of 26 patients with essential hypertension associated with coronary artery disease confirmed by coronary angiography was also measured,and the baPWV of 25 control group's patients was measured.Results:baPWV was significantly higher in patients with essential hypertension than that in contral group,and baPWV is much higher in patients with essential hypertension associated with coronary artery disease than that in patients with essential hypertension.Conclusions:The results suggest that vascular lesion is exsist in patients with essential hypertension,and the vascular stiffness in patients with essential htpertension associated with coronary artery disease is increased than that in patients with essential hypertension.
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Objective:To investigate the long effect of pereutaneous coronary intervention(PCl)on heart rate variability(HRV) in patients with coronary artery disease(CAD),and to evaluate the prognosis of patients with CAD receiving PCI.Methods:To choose 32 patients confirmed by coronary arteriography and suitable for PCl,and to choose 32 control patients with non-CAD confirmed by coronary arteriography,HRV indices were analyzed hefore PCI and Iweek,Imonth,3months,6months,lyear after PCI.Results:HRV indices were decreased in patients with CAD,HRV was lower in patients in lweek after PCI than that before PCI,HRV was gradually increased in lmonth and there was significantly improved in 6months after PCI,and nearly to the level of control group in one year.Conclusion:HRV is low in the patients with CAD,there is slightly decreased in the early stage of PCl,but the long effect of PCI on heart rate variability can be observed.